Most customers tolerate our supplements without incident; however, approximately 5 to 10% of customers (usually with an autoimmune condition) may experience a detoxification reaction. Detoxification reactions go by many different names including healing reactions, healing crises, cleansing reactions (or) Herxheimer reactions with hallmark symptoms of nausea, headache, hives, lethargy, dizziness and other flu-like symptoms. In this instance, detoxification reactions are generally an indication that detoxification pathways in the body are back online... cells suddenly have an opportunity to release an even greater than normal quantity of stored toxins, metabolic wastes, pathogens and unwanted material. Lowering the dose to just a 1/2 (half) to 1 capsule per day works for most. As always, we.