Active Iron causes 6X less gut irritation versus other oral iron, making it gentle on your stomach. GENTLE AND NON-CONSTIPATING: Active Iron Advance avoids common side effects and discomfort such as nausea and constipation; It is so gentle, it can be taken on an empty stomach avoiding digestive discomfort; Active Iron’s patent protected formula protects the stomach from the irritating effects of iron, making it easy to tolerate.